Palazzo Brunelleschi Bed & Breakfast is situated in the Florence Historic Centre district, 18 minutes' drive from Peretola airport. Guests who stay at the bed & breakfast can park their car nearby.

The accommodation is located within a 5-minute drive of the cathedral-flanked square "Piazza del Duomo" and Cathedral of Santa Maria del Fiore as well as about 5 minutes by car from Ponte Vecchio. The nearby places of worship include Santa Trinita (900 metres) and Basilica of Santa Croce in Florence (1.2 km). The hotel is a short distance from Church of Santo Spirito. There is Via de' Pucci bus stop approximately 5 minutes away by car.

Complete with a sofa and a work desk, the rooms also have soundproof windows for guests' comfort. A bidet, a separate toilet, and a shower, along with hairdryers and a shower cap, are provided.

Vivoli is located right near this Florence hotel and serves Mediterranean food.